Severe multivalvular heart disease: A new complication of the ergot derivative dopamine agonists
Identifieur interne : 002D04 ( Main/Exploration ); précédent : 002D03; suivant : 002D05Severe multivalvular heart disease: A new complication of the ergot derivative dopamine agonists
Auteurs : Judit Horvath [Suisse] ; Robin D. Fross [États-Unis] ; Galit Kleiner-Fisman [Canada] ; René Lerch [Suisse] ; Hans Stalder [Suisse] ; Suzanne Liaudat [Suisse] ; William J. Raskoff [États-Unis] ; Keith D. Flachsbart [États-Unis] ; Harry Rakowski [Canada] ; Jean-Claude Pache [Suisse] ; Pierre R. Burkhard [Suisse] ; Anthony E. Lang [Canada]Source :
- Movement disorders [ 0885-3185 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
We report on 4 new cases of valvular heart disease in Parkinson's disease patients treated with the ergot derivative dopamine agonists pergolide and cabergoline. Noninflammatory fibrotic degeneration of cardiac valves has been reported to occur in patients with carcinoid syndrome and to occasionally complicate therapies with the anti-migraine ergot alkaloid ergotamine and methysergide and with the appetite suppressants fenfluramine and dexfenfluramine. In these cases, the pathogenesis is suspected to involve serotonin-mediated abnormal fibrogenesis by means of the 5-HT2B receptors, which are expressed in the fibroblasts of heart valves. Based on strikingly similar echocardiographic and histopathological features, we strongly suspect that ergot-derived dopamine agonists may cause a valvular heart disease nearly identical to that seen in those conditions. These cases add to a rapidly growing and worrying list of similar published reports, suggesting that we may well be facing a novel, yet unrecognized, complication of this class of agents, which are widely used not only in Parkinson's disease but also in restless legs syndrome and various common endocrine dysfunctions. Therefore, until more is known about the true prevalence of this side effect, we propose that an assessment of cardiac function be performed before and in the course of a long-term therapy with ergot derivative dopamine agonists.
Affiliations:
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Fross</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, Kaiser Permanente Medical Centers</s1><s2>Hayward and San Francisco, California</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kleiner Fisman, Galit" sort="Kleiner Fisman, Galit" uniqKey="Kleiner Fisman G" first="Galit" last="Kleiner-Fisman">Galit Kleiner-Fisman</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centers, Department of Medicine, University Health Network, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lerch, Rene" sort="Lerch, Rene" uniqKey="Lerch R" first="René" last="Lerch">René Lerch</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Cardiology, University Hospital</s1><s2>Geneva</s2><s3>CHE</s3><sZ>4 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Stalder, Hans" sort="Stalder, Hans" uniqKey="Stalder H" first="Hans" last="Stalder">Hans Stalder</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Community Medicine, University Hospital</s1><s2>Geneva</s2><s3>CHE</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Liaudat, Suzanne" sort="Liaudat, Suzanne" uniqKey="Liaudat S" first="Suzanne" last="Liaudat">Suzanne Liaudat</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Community Medicine, University Hospital</s1><s2>Geneva</s2><s3>CHE</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Raskoff, William J" sort="Raskoff, William J" uniqKey="Raskoff W" first="William J." last="Raskoff">William J. Raskoff</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Cardiology, Kaiser Permanente Medical Centers, Hayward and San Francisco</s1><s2>California</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Flachsbart, Keith D" sort="Flachsbart, Keith D" uniqKey="Flachsbart K" first="Keith D." last="Flachsbart">Keith D. Flachsbart</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Cardiovascular Surgery, Kaiser Permanente Medical Centers, Hayward and San Francisco</s1><s2>California</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rakowski, Harry" sort="Rakowski, Harry" uniqKey="Rakowski H" first="Harry" last="Rakowski">Harry Rakowski</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Divisions of Neurology and Cardiology, Department of Medicine, University Health Network, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Pache, Jean Claude" sort="Pache, Jean Claude" uniqKey="Pache J" first="Jean-Claude" last="Pache">Jean-Claude Pache</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Pathology, University Hospital</s1><s2>Geneva</s2><s3>CHE</s3><sZ>10 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Burkhard, Pierre R" sort="Burkhard, Pierre R" uniqKey="Burkhard P" first="Pierre R." last="Burkhard">Pierre R. Burkhard</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital</s1><s2>Geneva</s2><s3>CHE</s3><sZ>1 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centers, Department of Medicine, University Health Network, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Complication</term><term>Dopamine agonist</term><term>Ergot derivatives</term><term>Heart disease</term><term>Nervous system diseases</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cardiopathie</term><term>Complication</term><term>Ergot dérivé</term><term>Système nerveux pathologie</term><term>Stimulant dopaminergique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report on 4 new cases of valvular heart disease in Parkinson's disease patients treated with the ergot derivative dopamine agonists pergolide and cabergoline. Noninflammatory fibrotic degeneration of cardiac valves has been reported to occur in patients with carcinoid syndrome and to occasionally complicate therapies with the anti-migraine ergot alkaloid ergotamine and methysergide and with the appetite suppressants fenfluramine and dexfenfluramine. In these cases, the pathogenesis is suspected to involve serotonin-mediated abnormal fibrogenesis by means of the 5-HT2B receptors, which are expressed in the fibroblasts of heart valves. Based on strikingly similar echocardiographic and histopathological features, we strongly suspect that ergot-derived dopamine agonists may cause a valvular heart disease nearly identical to that seen in those conditions. These cases add to a rapidly growing and worrying list of similar published reports, suggesting that we may well be facing a novel, yet unrecognized, complication of this class of agents, which are widely used not only in Parkinson's disease but also in restless legs syndrome and various common endocrine dysfunctions. Therefore, until more is known about the true prevalence of this side effect, we propose that an assessment of cardiac function be performed before and in the course of a long-term therapy with ergot derivative dopamine agonists.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Suisse</li><li>États-Unis</li></country><region><li>Californie</li><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Suisse"><noRegion><name sortKey="Horvath, Judit" sort="Horvath, Judit" uniqKey="Horvath J" first="Judit" last="Horvath">Judit Horvath</name></noRegion><name sortKey="Burkhard, Pierre R" sort="Burkhard, Pierre R" uniqKey="Burkhard P" first="Pierre R." last="Burkhard">Pierre R. Burkhard</name><name sortKey="Lerch, Rene" sort="Lerch, Rene" uniqKey="Lerch R" first="René" last="Lerch">René Lerch</name><name sortKey="Liaudat, Suzanne" sort="Liaudat, Suzanne" uniqKey="Liaudat S" first="Suzanne" last="Liaudat">Suzanne Liaudat</name><name sortKey="Pache, Jean Claude" sort="Pache, Jean Claude" uniqKey="Pache J" first="Jean-Claude" last="Pache">Jean-Claude Pache</name><name sortKey="Stalder, Hans" sort="Stalder, Hans" uniqKey="Stalder H" first="Hans" last="Stalder">Hans Stalder</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Fross, Robin D" sort="Fross, Robin D" uniqKey="Fross R" first="Robin D." last="Fross">Robin D. Fross</name></region><name sortKey="Flachsbart, Keith D" sort="Flachsbart, Keith D" uniqKey="Flachsbart K" first="Keith D." last="Flachsbart">Keith D. Flachsbart</name><name sortKey="Raskoff, William J" sort="Raskoff, William J" uniqKey="Raskoff W" first="William J." last="Raskoff">William J. Raskoff</name></country><country name="Canada"><region name="Ontario"><name sortKey="Kleiner Fisman, Galit" sort="Kleiner Fisman, Galit" uniqKey="Kleiner Fisman G" first="Galit" last="Kleiner-Fisman">Galit Kleiner-Fisman</name></region><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Rakowski, Harry" sort="Rakowski, Harry" uniqKey="Rakowski H" first="Harry" last="Rakowski">Harry Rakowski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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